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個(gè)人簡歷

神經(jīng)外科博士，留美博士后，主任醫(yī)師，1999于中國醫(yī)科大學(xué)獲臨床醫(yī)學(xué)學(xué)士學(xué)位;2003年于中國醫(yī)科大學(xué)獲神經(jīng)外科碩士學(xué)位; 同年于中國醫(yī)科大學(xué)附屬盛京醫(yī)院神經(jīng)外科工作，2005年留學(xué)日本就讀于日本浜松醫(yī)科大學(xué)神經(jīng)外科，2010年獲得醫(yī)學(xué)博士學(xué)位。同年留學(xué)美國俄亥俄州立大學(xué)醫(yī)學(xué)院神經(jīng)外科做博士后研究工作。2012年回國，在首都醫(yī)科大學(xué)三博腦科醫(yī)院神經(jīng)外科顱底腫瘤病區(qū)工作至今，任顱底病區(qū)副主任。長期從事神經(jīng)系統(tǒng)腦腫瘤的臨床和研究工作，在腦腫瘤診斷、手術(shù)治療方面有豐富的臨床經(jīng)驗(yàn)。

代表性文章

1.Liu H, Sun Y, Qi X, Gordon RE, O'Brien JA, Yuan H, Zhang J, Wang Z, Zhang M, Song Y, Yu C, Gu C: EZH2 Phosphorylation Promotes Self-Renewal of Glioma Stem-Like Cells Through NF-κB Methylation. Front Oncol. 2019 Jul 16;9:641.

2.Liu H, Sun Q, Sun Y, Zhang J, Yuan H, Pang S, Qi X, Wang H, Zhang M, Zhang H, Yu C, Gu C：MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation. Mol Cancer Res. 2017 Sep;15(9):1275-1286.

3. Zhang M, Wang Z, Zhang J, Zhang H, Gu C, Wang H, Yu C, Wu H：Metastases in cerebellopontine angle from the tumors of central nerve system. J Clin Neurosci. 2017 Aug;42:84-90.

4. Kim SH, Joshi K, Ezhilarasan R, Myers TR, Siu J, Gu C, Nakano-Okuno M, Taylor D, Minata M, Sulman EP, Lee J, Bhat KP, Salcini AE, Nakano I: EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner. Stem Cell Reports. 2015 Feb 10;4(2):226-38.

5. Minata M, Gu C, Joshi K, Nakano-Okuno M, Hong C, Nguyen CH, Kornblum HI, Molla A, Nakano I: Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition. PLoS One. 2014 Apr 16;9(4):e92546.

6. Gu C, Banasavadi-Siddegowda YK, Joshi K, Nakamura Y, Kurt H, Gupta S, Nakano I: Tumor-Specific Activation of the C-JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53-Dependent Manner. Stem Cell. 2013 May;31(5):870-81.

7. Li S, Gu C, Gao Y, Amano S, Koizumi S, Tokuyama T, Namba H: Bystander effect in glioma suicide gene therapy using bone marrow stromal cells. Stem Cell Res. 2012 Nov;9(3):270-6.

8. Gu C, Yokota N, Gao Y, Amano S, Koizumi S, Tokuyama T, Namba H: Targeting therapy against promyelocytic leukemia gene using arsenic acids in experimental intracranial medulloblastoma. Neurologia medico-chirurgica, 2012;52(2):62-7.

9. Amano S, Gu C, Koizumi S, Tokuyama T, Namba H:　Tumoricidal bystander effect in the suicide gene therapy using mesenchymal stem cells does not injure normal brain tissues. Cancer Lett. 2011 Jul 1;306(1):99-105.

10. Amano S, Gu C, Koizumi S, Tokuyama T, Namba H：Timing of ganciclovir administration in glioma gene therapy using HSVtk gene-transduced mesenchymal stem cells. Cancer Genomics Proteomics. 2011 Sep-Oct;8(5):245-50.

11. Koizumi S, Gu C, Amano S, Yamamoto S, Ihara H, Tokuyama T, Namba H：Migration of mouse-induced pluripotent stem cells to glioma-conditioned medium is mediated by tumor-associated specific growth factors. Oncol Lett. 2011 Mar;2(2):283-288.

12. Gu C, Yokota N, Gao Y, Yamamoto J, Tokuyama T, Namba H: Gene expression of growth signaling pathways is up-regulated in CD133-positive medulloblastoma cells. Oncol Lett. 2011 Mar;2(2):357-361.

13. Gao Y, Gu C, Li S, Tokuyama T, Yokota N, Nakayama KI, Kitagawa M, Namba H：p27 modulates tropism of mesenchymal stem cells toward brain tumors. Exp Ther Med. 2010 Jul;1(4):695-699.

14. Gu C, Li S, Tokuyama T, Yokota N, Namba H: Therapeutic effect of genetically engineered mesenchymal stem cells in rat experimental leptomeningeal glioma model. Cancer Lett. 291: 256–262, 2010.

15. Amano S, Li S, Gu C, Gao Y, Koizumi S, Yamamoto S, Terakawa S, Namba H: Tumoricidal bystander effect-mediated suicide gene therapy of glioma using genetically engineered bone marrow-drived mesenchymal stem cells. Int J Oncol. 35: 1265-1270, 2009.